Biomarkers are biochemical indicators that characterize a physiological or pathological process, and their measurement provides insight into the biological process in which the organism is currently engaged. In disease research, biomarker detection plays an important role in disease identification, early diagnosis, prevention and therapeutic monitoring. Quantitative biomarker imaging can be performed at different biological levels, such as molecular, cellular and individual levels. By analyzing and interpreting the imaging data, researchers can better understand the spatial and functional colocalization relationships of biomarkers, thus revealing their mechanisms of action in disease occurrence and action.

Services Overview

CD BioSciences provides biomarker quantification and colocalization analysis services using immunohistochemistry (IHC), immunofluorescence (IF), and histological staining techniques to help researchers understand the distribution and structural changes of relevant biomarkers in tissue samples. Traditional IHC slice analysis often relies on subjective interpretations and scoring systems by pathologists, which are prone to operational errors. CD BioSciences utilizes machine learning and accurate image processing techniques to enable large-scale quantitative analysis of images in shorter periods of time, avoiding manual errors.

Biomarker Quantification and Colocalization Analysis Services

Digital pathology biomarker quantification analysis services

CD BioSciences offers digital pathology biomarker quantitative analysis services, which provide clients with accurate quantitative data by digitizing slide samples using advanced scanning equipment and generating high-resolution images, and then analyzing the digital sections at high resolution and high speed through artificial intelligence (AI) algorithms and machine learning (ML) methods. Typical metrics we are able to quantify include:

➢ Total biomarker stain area
➢ Biomarker localization at the subcellular level
➢ Positive biomarker expression at the cellular level

Biomarker colocalization analysis services

CD BioSciences combines fluorescence microscopy and computer technology to provide biomarker colocalization analysis services to our clients. Our services mainly include the following:

Qualitative analysis of colocalization

By observing the fluorescence microscope image, we can determine the co-localization of two labeled molecules, and visually display the colocalization results of the two molecules for clients.

Quantification analysis of colocalization

We provide quantification colocalization analysis based on image analysis. By calculating the intensity and spatial overlap of fluorescent signals, we can quantify the colocalization relationship between two marker molecules.

Biomarker co-expression assessment

By analyzing digital section images we can assess the co-expression of different biomarkers, helping researchers to determine the degree of overlap and interrelationships between biomarkers, and revealing the interactions between biomarkers.

Analysis of biomarker co-localization with other cell types

Our service can also analyze the co-localization between biomarkers and other cell types (e.g., immune cells, tumor cells, etc.). By measuring the spatial relationship and proximity between them, researchers can understand the interactions between different cell types and biomarkers.

Deliverables

➢ Quantification data report
➢ Experimental protocol

Our Advantages

➢ Quantitative analysis
We accurately analyze biomarker regions in tissue samples through objective and quantitative assessment, reducing subjective interpretation and increasing the reliability of results.
➢ Biomarker colocalization
We can evaluate the co-localization relationship between multiple biomarkers and gain a comprehensive understanding of their spatial interrelationships and functional implications.
➢ Efficient and fast
With computational technology, we are able to process large numbers of tissue sections quickly, saving our clients' time and resources.
➢ Professional analysis
Our team of professional scientists will apply expertise and technology to interpret and analyze bioimage data to ensure accurate and reliable results for clients' research.

CD BioSciences has a professional team and advanced imaging equipment. The whole process of biomarker quantification and colocalization analysis services is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!