Services Overview

CD BioSciences provides clients with accurate bone tissue images and quantitative analysis reports through advanced imaging technology and computer-aided analysis. Our services mainly include cartilage tissue morphology analysis, fracture healing observation, and bone tissue tumor morphology assessment. The quantitative data and results obtained can help clients study the physiological processes of bone tissue, understand the development of bone-related diseases, and evaluate the efficacy of drugs.

Fig. 1 Bone tissue structure with bone plates and haversian canals under the microscope.

Bone Tissue Morphology Imaging Services

Cartilage morphology analysis services

CD BioSciences provides cartilage morphology imaging analysis services to help clients quantitatively and qualitatively characterize the morphology of cartilage such as articular cartilage and epiphyseal plate cartilage. Our services include, but are not limited to:

Bone structure changes due to cartilage loss and articular cartilage area analysis

We will provide our clients with comprehensive reports that include the following commonly analyzed parameters:

• ACV (Articular Cartilage Volume)
  Assessment of changes in cartilage tissue through precise measurement of the volume of articular cartilage by imaging.

• Tb.BV/Tb.TV
  This parameter is commonly used to assess the ratio of trabecular volume to total volume, providing information on the structural characteristics of the bone.

• Sb.Ch.Th (Subchondral Plate Thickness)
  Measures the thickness of the subchondral plate and assesses the structural characteristics of the bone associated with articular cartilage.

Epiphyseal plate cartilage area quantification analysis

By using imaging techniques for quantitative analysis of epiphyseal plate cartilage morphology, we can measure and calculate the actual surface area of the epiphyseal plate cartilage to evaluate the growth and development of the skeleton. The following parameters are commonly used in our deliverables:

• Chondrocyte Number
  Calculates the number of chondrocytes in the cartilage of the epiphyseal plate, providing the quantitative analysis of cellular composition.

• BrdU Positive Chondrocyte Number
  Measures the number of positive chondrocytes labeled with BrdU (bromodeoxyuridine) and assesses chondrocyte proliferation.

Fig. 2 Bone histologic samples with cartilaginous structures under the microscope.

Dental-metal implant analysis services

We can evaluate and analyze the morphological relationship between dental implants and surrounding bone tissue for our clients, providing raw images and quantitative analysis reports that include the following data:

• Metal Eroded Perimeter (Mt.E.Pm)
• Metal Bone Boundary (Mt.B.Bd)
• Metal Bone Interface/ Bone Surface
• Metal Eroded Interface/ Bone Surface

Morphometric analysis of fracture healing

Evaluation and analysis of the morphology and healing of bone tissue during the fracture healing process helps our clients to understand the progress of fracture healing and the extent of bone tissue repair. We will deliver the raw images and osteometrics report, including the following parameters:

• Vessel Number
• Total Callus Area
• Bone Fraction/Total Callus
• Cartilage Fraction/Total Callus

Bone tissue tumor morphology analysis services

Using imaging techniques allows to measure the number and area of tumors in the bone tissue and to characterize the morphological changes caused by the tumors. Raw images and detailed reports containing the following parameters are provided:

• Tu.V (Tumor volume)
• BV/TV
• Tu.V/BV
• Tu.S/BS
• OC.S/BS

CD BioSciences has a professional team and advanced imaging equipment. The whole process of bone tissue morphology imaging services is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!