Brain injuries can be categorized as congenital brain injuries, acquired brain injuries (ABI), traumatic brain injuries (TBI), and mild traumatic brain injuries (mTBI)/concussions. Traditional 2D sectioning methods are disruptive in the study of brain injury and have limitations in continuous structural characterization. However, with precise 3D visualization and molecular characterization, the brain tissue structure of brain injury can be observed.

Fig. 1 Histopathological changes in rat brains two weeks after ESW-induced focal injury (Huang A.PH., et al. 2019).

Services Overview

CD BioSciences provides specialized brain injury imaging services. We utilize 3D imaging technology to provide our clients with detailed brain injury information, including localization of brain injury regions and characterization of injury morphology. According to the client's research, we will provide comprehensive brain injury disease models, including impact brain injury (TBI) models, epilepsy models, ischemia/reperfusion models, and genetically modified animal models, to comprehensively analyze the various diseases induced by brain injury as well as different types of brain injuries.

Brain Injury Imaging Services

High-performance small animal magnetic resonance imaging (MRI)

We provide the small animal MRI platform, which allows for the capture of high-resolution 3D digital morphology images, which can be used to detect various brain injury lesions for our clients.

Rat repetitive mild head injury imaging analysis

Utilize rat models to study repetitive mild brain injury in the fully awake state. Simulates real-life brain injury situations that occur to help optimize and develop effective protective measures.

• Biomechanical measurements related to impact velocity, head acceleration, head velocity changes and energy transfer.
• Conducting translational head injury studies to translate biomechanical measurements into head injury assessment metrics.
• Design and development of repetitive mild injury models in the fully awake state. Used to achieve repetitive mild injuries and obtain accurate biomechanical measurements.

Drug-induced brain injury analysis

Some drug ingredients (e.g., pilocarpine) can induce epilepsy and morphological neuronal damage in the rat brain. We will analyze a rat model of drug-induced brain damage and observe the following multiple brain regions to assess the morphological effects of drugs on the brain.

• Pyriform cortex
• Lateral dorsal nucleus of the thalamus
• Hippocampus and substantia nigra

Supplementary services

In addition to imaging services, we offer comprehensive imaging services support. Including:

• Consultation on compound efficacy and testing procedures
• Assistance with study protocols and experimental design
• Collection of blood tissue samples
• Animal preparation before imaging (such as surgery, localization, detection and drug delivery)
• Data collection and analysis

Our Technology Platform

• Functional Magnetic Resonance Imaging (fMRI)
  For non-invasive assessment of functional changes in damaged brain regions and relevant cognitive and motor functions.
• Pharmacological MRI (phMRI)
  To assess the effects of therapeutic drugs on damaged brain regions, to optimize drug design, and to understand the mechanism of action of drugs on brain injury.

CD BioSciences has a professional team and advanced imaging equipment. The whole process of brain injury imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us. We can also customize brain injury imaging services for you according to specific needs.

1. Huang A.PH., et al. Cavitation-induced traumatic cerebral contusion and intracerebral hemorrhage in the rat brain by using an off-the-shelf clinical shockwave device. Sci Rep 9, 2019, 15614.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!