Cat B Fluorescent Probe
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Catalog NO: VIR030117
Size: 1 Vial (10 doses)
Subtype: Cat B 680 FAST Fluorescent Probe;
Cat B 750 FAST Fluorescent Probe
Cat B 750 FAST Fluorescent Probe
Introduction:Cat B Fluorescent Probe enable non-invasive in vivo detection of disease status and progression in oncology, inflammation and other areas associated with Cat B activity. Associated with tumor aggression, cathepsins are a family of proteases that are pivotal components of signaling pathways that can enhance cancer cell growth and inflammation. Within the human lysosomal cysteine cathepsin family, there are 11 members, including cathepsin B, L, S, and Plasmin. As a family, cysteine cathepsins are involved in the response to anticancer therapy within the tumor microenvironment and play crucial roles in the development of resistance to therapeutics. In particular, cathepsin B expression correlates with the invasive and metastatic capabilities of many tumors, such as in breast cancer where high expression levels of cathepsin B have been linked to highly aggressive tumors. Cathepsin B is also upregulated in a variety of inflammatory cells, including eosinophils, neutrophils, and macrophages.
Wavelength:680mn; 750nm
Category:Fluorescent Probes
Shipping Condition:Ambient
Therapeutic Area:Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
Fluorescent Agent Type:Activatable
Optical Imaging Classification:Fluorescence Imaging
Intended Use:For research use only. Not for use in diagnostic procedures.