When pathogens such as viruses and bacteria infect the host, they can elicit immune responses, including innate and adaptive immune responses. Innate immunity is a non-specific rapid response to any pathogen, while adaptive immune response is a human immune response to a specific antigen with extremely high specificity. Typically, pathogen infection causes a range of diseases. Therefore, imaging analysis of host immune responses following pathogen infection is critical for disease prevention and treatment.

Figure 1. Visualizing innate immune cell responses to bacterial infections in different organs using intravital microscopy (Scott B N V, et al. 2019).

Imaging Analysis of Host's Immune Response to Infection

Microscopic examination using immunofluorescence or immunochemical labeling provides a reliable means of monitoring T and B cell responses. However, this method needs to add a large number of cells that will introduce artifacts and affects the reliability of the findings. The advent of intravital microscopy has allowed researchers to observe multiple immune cell interactions in real-time in living animals, helping us understand how the host immune system responds to these infections.

CD BioSciences has been committed to the development of fluorescent dyes and imaging technology for many years. We can use multiphoton and confocal microscopy to understand host-pathogen interactions to determine which cells are involved in clearing specific pathogens.

The Workflow of Imaging Analysis of Host's Immune Response to Infection

The following are the specific steps of host's immune response imaging analysis

Delivery

Determine how T cells, B cells, and antigen presenting cells interact
Other data that you need

Our Advantages

• Efficient and rapid capture of immune response events in real time
• Allows visual analysis of more cell types
• Better tissue penetration, minimal light damage
• Experienced scientists provide experimental consultation
• Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of host's immune response imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.  

1. Khanna K M, Leo Lefrançois. Imaging—and Imagining—Immune Responses to Infections[J]. Microbe, 2011, 6(2):63.
2. Giovanni M D, Iannacone M. In vivo imaging of adaptive immune responses to viruses[J]. Current Opinion in Virology, 2018, 28:102-107.
3. Scott B N V, Sarkar T, Kratofil R M, et al. Unraveling the host's immune response to infection: Seeing is believing[J]. Journal of Leukocyte Biology, 2019, 106(2).

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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!