Imaging in Animal Model of Acute Injury
At CD BioSciences, we offer comprehensive animal modeling services to support acute injury reasearch, coupled with advanced imaging modalities such as micro-CT, fluorescence imaging, and optical coherence tomography (OCT), enabling detailed characterization of injury and evaluation of novel therapeutic interventions. Our expertise spans various animal models of acute injury, supporting pathological research and preclinical drug development.
Roles of Imaging Technology in Preclinical Acute Injury Research
Imaging technology plays a crucial role in preclinical acute injury research and drug development, providing non-invasive, real-time visualization of injury progression, therapeutic response, and tissue repair.
Figure 1. Magnetic resonance imaging (MRI) in mouse models of renal injury. (Mukherjee S, et al. 2024)
What Can We Do for the Construction and Imaging of Animal Models of Acute Injury?
Our animal modeling and imaging services encompass various acute injury diseases, such as acute nerve, liver, kidney, and lung injury. We utilize specific methods, imaging techniques, and evaluation indicators to provide comprehensive data.
| Disease Types | Modeling Methods | Imaging Techniques | Examination Indicators |
| Acute Nerve Injury | Crush injury, transection, ligation, nerve compression. | Electrophysiology (nerve conduction studies), fluorescence microscopy (axonal regeneration), micro-CT (nerve structure), histopathological staining. | Nerve conduction velocity, axonal regeneration rate, myelin sheath integrity, functional recovery (e.g., behavioral tests). |
| Acute Liver Injury | Ischemia/reperfusion injury, toxin administration (e.g., acetaminophen, CCl4), bile duct ligation. | Bioluminescence imaging (inflammation), micro-CT (liver structure), fluorescence microscopy (cellular damage). histopathological staining. | Serum liver enzyme levels (ALT, AST, bilirubin), liver cell necrosis, inflammation, fibrosis. |
| Acute Kidney Injury | Ischemia/reperfusion injury, nephrotoxin administration (e.g., cisplatin, gentamicin), ureteral obstruction. | Micro-CT (kidney structure), fluorescence microscopy (cellular damage). Histology is also employed. | Serum creatinine and BUN levels, urine output, proteinuria, tubular necrosis, inflammation. |
| Acute Lung Injury | Bleomycin administration, lipopolysaccharide (LPS) instillation, acid aspiration. | Micro-CT (lung structure), fluorescence imaging (inflammation). Histology is also employed. | Bronchoalveolar lavage (BAL) fluid analysis (inflammatory cells, cytokines), lung wet/dry weight ratio, pulmonary edema, lung compliance. |
Applications of Our Disease Modeling and Imaging Services for Acute Injury
Biomarker Discovery
The detailed data generated by our imaging and analysis techniques can contribute to the identification of novel biomarkers for acute injury, aiding in the development of diagnostic technologies.
Disease Mechanism Research
Our models allow for detailed investigation of the pathophysiological mechanisms underlying acute injury, providing insights into the cellular and molecular events driving tissue damage and repair. Advanced imaging techniques enable visualization of these processes in vivo.
Drug Development
Our services facilitate preclinical drug development by providing a platform for evaluating the efficacy and safety of novel therapeutic agents in relevant animal models of acute injury. Through quantitative imaging data, we support in precise assessment of treatment response and identification of optimal dosing strategies.
Toxicity Studies
We specialize in assessing the potential toxicity of drug candidates, identifying potential adverse effects and informing safe dosing regimens.
At CD BioSciences, we offer comprehensive disease modeling and imaging services to support acute injury research. Our capabilities span nerve, liver, kidney, and lung injury models, with expertise in customized model development, advanced imaging techniques like micro-CT and fluorescence microscopy, and in-depth data analysis. Contact us today to discuss your specific needs.
- Mukherjee S, et al. Multiparametric MRI based assessment of kidney injury in a mouse model of ischemia reperfusion injury. Sci Rep. 2024, 14(1):19922.
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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!