Imaging in Cardiovascular Disease Models
CD BioSciences offers cardiovascular disease modeling and imaging services, providing comprehensive solutions for preclinical research. We specialize in developing a wide range of animal models, including surgically induced myocardial infarction models and genetically modified animal models, tailored to specific cardiovascular diseases such as heart failure, atherosclerosis, and thrombosis. Our advanced imaging capabilities encompass echocardiography, cardiac MRI, PET/SPECT, intravital microscopy, and optical imaging, enabling detailed, real-time visualization and quantification of cardiac anatomy, function, blood flow, and molecular processes.
Roles of Imaging Technology in Preclinical Cardiovascular Disease Research
Imaging technology plays a pivotal role in preclinical cardiovascular disease research by providing essential tools for visualizing and understanding the complex physiological and pathological processes of the heart and vascular systems. Advanced imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound offer non-invasive methods to evaluate myocardial perfusion and metabolism in animal models, facilitating the understanding of cardiovascular disease mechanisms and the evaluation of novel therapeutic agents.
Figure 1. Myocardial metabolic imaging in rats. (Sosnovik DE, Scherrer-Crosbie M. 2022)
What Can We Do for Cardiovascular Disease Modeling & Imaging?
Customized Cardiovascular Disease Models
| Model Types | Modeling Methods |
| Myocardial Infarction |
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| Heart Failure |
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| Atherosclerosis |
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| Thrombosis |
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| Arrhythmias |
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In addition to these specific models, we offer customized model development tailored to individual research needs, including the use of specific animal species, induction methods, and combination models.
Preclinical Cardiovascular Disease Imaging Services
| Service Items | Imaging Techniques | Detection Indicators |
| Imaging the Viscoelastic Properties of the Myocardium |
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Myocardial stiffness, viscosity, and elasticity |
| Imaging of Myocardial Metabolism |
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Glucose uptake, fatty acid oxidation, metabolic substrate utilization, and changes in metabolite concentrations |
| Imaging of Myocardial Perfusion |
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Myocardial blood flow, regional perfusion defects, and coronary artery stenosis |
| Imaging of Myocardial Mechanics |
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Left ventricular ejection fraction, wall thickening, myocardial strain and strain rate, and ventricular volumes |
| Imaging of Myocardial Microstructure |
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Myocardial fiber orientation, cellular organization, and changes in tissue architecture. |
| Imaging of Myocardial Inflammation |
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Inflammatory cell infiltration, cytokine expression, and activation of inflammatory pathways. |
| Imaging of Myocardial Healing and Fibrosis |
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Scar tissue formation, collagen content, microvessel density, and vascular remodeling. |
| Imaging of Myocardial Regeneration |
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Engraftment of transplanted cells, cell survival, and differentiation |
| Imaging of RV and Pulmonary Circulation |
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Right ventricular size and function, pulmonary artery pressure, and pulmonary vascular resistance |
| Real-time Microcirculation Imaging |
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Capillary density, blood flow velocity, and leukocyte-endothelial interactions. |
CD BioSciences excels at customizing experimental models that recapitulate a spectrum of cardiovascular diseases, coupled with advanced imaging techniques to explore the complexities of cardiac function and pathology. Our services are designed to advance cardiovascular research and drug development. Contact us today to discover how our tailored services can accelerate your studies.
- Sosnovik DE, Scherrer-Crosbie M. Biomedical imaging in experimental models of cardiovascular disease. Circ Res. 2022, 130(12):1851-1868.
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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!