Imaging in Chronic Disease Models
CD BioSciences offers comprehensive chronic disease modeling and imaging services, encompassing both in vitro (e.g., cell cultures, organoids) and in vivo models, coupled with advanced imaging techniques such as multiphoton microscopy, optical coherence tomography (OCT), and micro-CT.
Roles of Imaging Technology in Preclinical Chronic Disease Research
Chronic diseases are complex, often involving slow, progressive changes at the cellular and tissue levels. Imaging technologies play a vital role in advancing chronic disease research by supporting detailed characterization of disease phenotypes, evaluation of novel therapeutic interventions, and mechanistic studies of disease pathogenesis.
Figure 1. T1 rho images of chronic kidney disease rats (Kim SY, et al. 2023)
What Can We Do for Chronic Disease Modeling & Imaging?
At CD BioSciences, our services are tailored to meet specific research needs, offering customized model development, advanced imaging techniques, and comprehensive data analysis to support your preclinical research.
| Disease Types | Modeling Methods | Imaging Technologies | Evaluation Indicators |
| Chronic Kidney Disease |
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Serum creatinine and BUN levels, albuminuria, glomerular filtration rate (GFR), histological changes (fibrosis, inflammation). |
| Chronic Inflammation |
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Inflammatory cytokine levels, immune cell infiltration, histological changes (inflammation, fibrosis) |
| Chronic Obstructive Pulmonary Disease (COPD) |
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Lung function tests (FEV1, FVC), inflammatory cell infiltration, mucus production, and histological changes (emphysema, fibrosis). |
| Chronic Pain |
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Neuronal excitability, histological changes (nerve fiber degeneration) |
| Chronic Liver Diseases |
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Serum liver enzyme levels (ALT, AST), histological changes (fibrosis, inflammation), liver function tests. |
Applications of Our Chronic Disease Modeling & Imaging Services
Mechanistic Studies of Chronic Disease
We utilize advanced imaging technologies, such as multiphoton microscopy and fluorescence techniques to provide crucial data into disease pathogenesis that would be impossible to obtain through traditional methods alone, helping researchers unravel complex disease mechanisms.
Biomarker Discovery and Validation
Our advanced imaging services reveal subtle changes in tissue structure and function, providing crucial data indicative of disease progression and facilitating the identification and validation of novel biomarkers.
Preclinical Drug Development and Evaluation
Our models and imaging capabilities provide a robust platform for preclinical drug testing. We can assess the efficacy and safety of novel therapeutic agents in related disease models, using imaging technologies to monitor drug distribution, target engagement, and therapeutic response in real-time.
With diverse models and advanced imaging techniques, CD BioSciences is dedicated to supporting chronic disease research, enabling a deeper understanding of disease mechanisms and facilitating the development of novel drug candidates. Our expertise spans model development, imaging analysis, and data interpretation. Contact us today to discuss your research needs and explore how our services can advance your project.
- Kim SY, et al. Quantitative magnetic resonance imaging of chronic kidney disease: an experimental in vivo study using rat chronic kidney disease models. Acta Radiol. 2023, 64(1):404-414.
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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!