Imaging in Dermatology Models
CD BioSciences is a research service provider for preclinical dermatological research, specializing in the construction and imaging of skin disease models. Our expertise encompasses the development of in vitro and in vivo models, including 3D skin constructs, humanized animal models, and organ-on-a-chip platforms, that accurately mimic human skin biology and disease. We utilize state-of-the-art imaging modalities, such as high-frequency ultrasound, OCT, confocal microscopy, multiphoton microscopy, and fluorescence imaging, to visualize, characterize, and quantify disease progression and treatment responses.
Roles of Imaging Technology in Preclinical Dermatology Research
Imaging technologies are increasingly important in preclinical dermatological research, offering powerful tools to visualize and quantify skin structure, function, and disease progression in animal models. Techniques such as high-frequency ultrasound and optical coherence tomography (OCT) provide non-invasive, high-resolution images of skin layers, allowing researchers to assess epidermal thickness, dermal collagen content, and vascularization.
Figure 1. Imaging of psoriasis using raster-scan optoacoustic mesoscopy (RSOM). (Hindelang B, et al. 2019)
What Can We Do for the Construction and Imaging of Skin Disease Models?
| Disease Types | Modeling Services | Imaging Techniques | Detection Indicators |
| Psoriasis |
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Epidermal thickness, dermal inflammation, blood vessel density, immune cell infiltration (e.g., T cells, neutrophils), and expression of inflammatory markers (e.g., IL-17, TNF-α). |
| Scleroderma |
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Dermal thickness, collagen content and organization, skin elasticity, and fibroblast activation markers (e.g., α-SMA). | |
| Malignant Skin Lesions (e.g., Melanoma, Squamous Cell Carcinoma) |
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Tumor size, depth of invasion, vascularization, cell proliferation, apoptosis, and expression of tumor markers | |
| Atopic Dermatitis |
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Epidermal thickness, skin barrier integrity, transepidermal water loss (TEWL), immune cell infiltration (e.g., eosinophils, mast cells), and expression of inflammatory cytokines | |
| Acne |
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Sebaceous gland size and activity, follicular inflammation, bacterial load, and sebum production. | |
| Androgenetic Alopecia |
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Hair follicle density, size, and growth cycle stage, hair shaft thickness, and dermal papilla size. |
Applications of Our Dermatology Model Construction and Imaging Services
- Evaluating the efficacy of novel topical, systemic, or biologic therapies for inflammatory skin conditions such as psoriasis, atopic dermatitis, and contact dermatitis.
- Investigating the pathogenesis of autoimmune and genetic skin disorders through the use of genetically engineered models.
- Testing the efficacy and safety of cosmetic formulations.
CD BioSciences offers comprehensive skin disease modeling and imaging services, providing cutting-edge solutions for preclinical dermatology research. We specialize in developing a wide range of in vitro and in vivo models tailored to specific skin diseases and have state-of-the-art imaging capabilities to conduct detailed, non-invasive assessments of skin structure, function, and disease progression. Contact us today to discuss your specific research needs and discover how our services can accelerate your dermatological research and development efforts.
- Hindelang B, et al. Non-invasive imaging in dermatology and the unique potential of raster-scan optoacoustic mesoscopy. J Eur Acad Dermatol Venereol. 2019, 33(6):1051-1061.
*If your organization requires the signing of a confidentiality agreement, please contact us by email.
Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!