Imaging in Disease Models
Through MRI, PET, CT scans and other advanced imaging technologies, CD BioSciences can visualize structural and functional changes at the tissue level and provide real-time views of cellular-level changes, such as shifting metabolism or cellular interactions. Our integrated imaging platform can provide a complete understanding of disease mechanisms, test drug efficacy, and promote new diagnostics and therapies.
Roles of Imaging Technology in Preclinical Disease Model Research
Imaging technologies play a crucial role in preclinical disease model research, allowing researchers to monitor anatomical changes, physiological processes, and molecular events in living organisms over time. For example, techniques like magnetic resonance imaging (MRI) and computed tomography (CT) can be used to assess tumor growth and metastasis, while positron emission tomography (PET) and single-photon emission computed tomography (SPECT) can track the distribution and efficacy of therapeutic agents. Optical imaging methods, such as bioluminescence and fluorescence imaging, enable the visualization of cellular and molecular processes at high resolution.
Figure 1. Methods and procedures for in vivo and ex vivo imaging in rat brain tumor models. (Scarpelli ML, et al. 2020)
Disease Modeling and Imaging Services
| Disease Modeling | Imaging Services |
| Acute Injury Models | We offer high-resolution imaging to assess the immediate and short-term effects of injury. This includes techniques such as fluorescence microscopy to visualize cellular damage and inflammation, and optical coherence tomography (OCT) for high-resolution imaging of tissue microstructure. |
| Chronic Disease Models | Longitudinal studies of chronic disease progression are supported by non-invasive imaging modalities such as bioluminescence imaging (BLI) and fluorescence molecular tomography (FMT) to monitor disease development and treatment response over time. MRI and CT scanning can also be used for anatomical assessments. |
| Tumor Models | We provide a range of imaging services for tumor models, including BLI and FMT for monitoring tumor growth and metastasis, micro-CT for high-resolution anatomical imaging, and fluorescence microscopy for detailed cellular analysis of the tumor microenvironment. |
| Ophthalmic Disease Models | High-resolution imaging of the eye is crucial. We utilize OCT for detailed visualization of retinal structure and function, and confocal microscopy for cellular-level analysis of retinal changes. |
| Dermatology Models | Our imaging services for skin disease models include confocal microscopy for high-resolution imaging of skin layers and cellular changes, and multiphoton microscopy for visualizing deeper tissue structures and cellular interactions. |
| Infectious Disease Model | We utilize BLI and FMT to monitor infection progression and spread in vivo, while fluorescence microscopy allows for detailed visualization of bacterial colonization and immune cell responses. |
| Cardiovascular Disease Models | Our services include echocardiography for functional assessment of the heart, micro-CT for high-resolution anatomical imaging of blood vessels, and fluorescence microscopy for cellular-level analysis of vascular changes. |
| CNS Disease Models | At CD Biosicences, our research team employs cutting-edge imaging techniques, including two-photon microscopy for visualising neuronal activity and structure in brain tissue and MRI for assessing brain morphology and function in vivo. |
Applications of Our Disease Modeling and Imaging Services
Disease Mechanism Studies
We provide detailed insights into the underlying mechanisms driving disease pathogenesis, helping clients understand the complex interplay of genetic, environmental, and cellular factors.
Biomarker Discovery
Our advanced imaging techniques allow for the identification and validation of novel biomarkers associated with disease progression and treatment response.
Drug Discovery and Development
CD BioSciences provides preclinical evaluation services for new drug candidates, assessing efficacy, toxicity, and pharmacokinetics profiles.
Depending on your requirements, CD BioSciences screens and selects the most suitable disease models and imaging techniques. We also optimize the most appropriate imaging modes and help scientists acquire and analyse data to achieve their discovery goals. For any inquiries, please contact us.
- Scarpelli ML, et al. A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging. Sci Rep. 2020, 10(1):17324.
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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!