At CD BioSciences, we offer comprehensive tumor model construction and imaging analysis services, encompassing a wide range of tumor types and models, from orthotopic xenografts to genetically engineered mouse models. Our platform is equipped with advanced imaging modalities such as bioluminescence imaging (BLI), fluorescence imaging, micro-CT, and PET/SPECT, coupled with sophisticated image analysis techniques to provide quantitative and qualitative data, supporting preclinical oncology research.

Roles of Imaging Technology in Preclinical Oncology Research

Imaging technology is indispensable in tumor research, providing real-time visualization of tumor growth, metastasis, and response to therapy. This allows for precise quantification of tumor burden, detailed assessment of treatment efficacy, and mechanistic insights into tumor biology.

Figure 1. Fluorescent protein imaging and MRI of primary pancreatic tumors in orthotopic nude mouse models. (Bouvet M, Hoffman RM. 2015)

What Can We Do for Tumor Model Construction & Imaging?

Tumor Model Construction

We construct a variety of tumor models tailored to specific research needs, including orthotopic xenografts, genetically engineered animal models, and patient-derived xenografts (PDXs). Whether in vitro 3D cultures or in vivo models, our services are designed to provide meaningful insights into tumor growth dynamics, cellular interactions, and response to drugs.

Monitoring Vascular Morphology and Permeability Changes

Employing advanced imaging techniques to visualize and quantify changes in tumor vasculature.

• Technologies/Methods: Multiphoton microscopy, micro-CT, fluorescence imaging (using vascular-specific dyes), dynamic contrast-enhanced MRI (DCE-MRI).
• Analysis Services: Quantitative assessment of vessel density, diameter, tortuosity, and permeability, 3D vascular imaging.

Evaluation of Tumor Cell Growth and Death

Utilizing imaging techniques to monitor tumor growth and assess the effects of therapeutic interventions on tumor cell viability.

• Technologies/Methods: Bioluminescence imaging (BLI), fluorescence imaging (using cell-cycle specific dyes or apoptosis markers), micro-CT, Diffusion-weighted MRI.
• Analysis Services: Quantitative measurement of tumor volume, growth rate, cell death, and markers of cell proliferation and apoptosis.

Tracking Tumor Cell Dissociation

Utilizing imaging techniques to track the movement and dissemination of tumor cells.

• Technologies/Methods: Intravascular multiphoton microscopy, fluorescence imaging.
• Analysis Services: Visualization and quantification of cell migration, invasion, and extravasation.

Evaluation of Circulating Tumor Cells (CTCs) and Metastasis Formation

Employing techniques to detect and quantify CTCs and assess the formation of metastases.

• Technologies/Methods: Fluorescence imaging, bioluminescence imaging, micro-CT, PET/CT.
• Analysis Services: Quantification of CTCs, detection and characterization of metastatic lesions.

Applications of Our Tumor Model Construction & Imaging Services

• Biomarker Discovery and Validation: Identifying potential biomarkers for diagnosis, prognosis, and treatment response.
• Preclinical Drug Discovery and Development: Evaluating the efficacy and safety of novel anti-cancer agents.
• Mechanism of Action Studies: Investigating how drugs affect tumor growth, angiogenesis, and metastasis.
• Immunotherapy Research: Evaluating the efficacy of immune checkpoint inhibitors and other immunotherapies.
• Combination Therapy Studies: Investigating the synergistic effects of combining different cancer treatments.
• Toxicity Studies: Assessing the side effects of new cancer drugs and treatment strategies.

CD BioSciences' comprehensive tumor model construction and advanced imaging services accelerate preclinical oncology research, providing crucial data on tumor growth, treatment response, and metastasis. We offer customized models and sophisticated imaging techniques, including bioluminescence, SPEC-CT, and PET-CT, for precise, quantitative analysis. Contact us today to discuss your research needs.

1. Bouvet M, Hoffman RM. Tumor imaging technologies in mouse models. Methods Mol Biol. 2015, 1267:321-48.

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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!