Biomarkers refer to biochemical indicators that can mark the structural or functional changes of organs, tissues, cells and subcellular, including nucleic acids, proteins, enzymes, carbohydrates, active molecules, etc. Tissue-specific biomarkers are often used to study pathological changes in diseases or to evaluate the safety and efficacy of new drugs. Therefore, imaging monitoring of biomarkers in tissues is important for disease diagnosis and new drug development.

Figure 1. Example of estrogen receptor quantification (Visiopharm) (Lara H, et al. 2021).

Imaging Monitoring of Biomarkers in Tissues

The most classical method applied to the detection of markers in tissues is immunohistochemistry, which in most cases uses enzyme-linked antibodies to develop color reactions and examine them under microscope. Although the method is widely used in medical testing, the technique requires very specialized operators and extremely stringent standards, and can only yield semi-quantitative results. Therefore, researchers need to develop imaging techniques that can quantitatively analyze biomarkers in tissues.

CD BioSciences is a biotechnology company, we have extensive experience in finding new biomarkers and monitoring biomarkers in tissues. We can use imaging mass spectrometry quantitative immunostaining technology to provide you with thousands of different molecular images, to quantify and localize biomarkers in tissues. This will help the development of new drugs and the diagnosis of diseases.

Our Services

Assess the concentration, morphology of biomarkers in tissues
Monitoring drug response biomarkers
Identifying new disease biomarkers

Our Advantages

• Tracking the changes of disease-related biomarkers in tissues
• Provides high-quality molecular images
• Experienced scientists provide experimental consultation
• Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of imaging monitoring of biomarkers in tissues is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.  

1. Muller P D, Rima, et al. Automated Morphological and Morphometric Analysis of Mass Spectrometry Imaging Data: Application to Biomarker Discovery[J]. Journal of the American Society for Mass Spectrometry, 2017.
2. Lara H, Li Z, Abels E, et al. Quantitative image analysis for tissue biomarker use: a white paper from the digital pathology association[J]. Applied Immunohistochemistry & Molecular Morphology: AIMM.

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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!