Services Overview

CD BioSciences provides comprehensive lung imaging services to help researchers analyze the characteristics and functions of lung organs and tissues. We utilize the latest imaging technologies and analytical tools to help our clients gain insight into the mechanisms of lung disease development and therapeutic approaches. Our lung imaging services include, but are not limited to, 3D lung organoid cultures, 3D imaging analysis, and real-time in vivo imaging analysis of animals. We will provide highly sensitive and accurate quantitative and qualitative imaging reports to support our clients' preclinical research and drug discovery.

Fig. 1 3D image of the secondary tuberculosis in the lung.

Lung Imaging Services

3D lung organoid culture imaging services

Lung organoids have similar characteristics to the human airways, such as alveolar structure, mucosal secretion, ciliary pulsation, and regenerative capacity. Such biological similarities allow us to deeply investigate the repair and regeneration mechanisms of lung injury and the changes in lung disease phenotypes. In addition, the lung organoid can also be used for toxicity assessment and drug testing applications. We will provide the following lung organoid imaging services:

Lung organoid culture

• Using primary human lung epithelial cells cultured in extracellular matrix (ECM) containing growth factors.
• Form 3D microtissue models with morphological and functional characteristics of the airways.
• Cells are capable of self-assembling to form a multispectral lung epithelium, including different cell populations.

3D assay and confocal imaging

• Utilize the transparency and light transmission characteristics of lung organoid to perform 3D biological assays and confocal imaging.
• Quantitative characterization of cellular contents, cell survival assessment, and cell classification for specific markers.
• Machine learning-based imaging analysis tracks object diameter, area growth, density, and volume.
• Use imaging analysis to enable 3D reconstruction and complex analysis of the lung organoid, including the study of cell morphology, activity, and differentiation markers.

Mouse lung tissue 3D imaging analysis service

Tissue clearing

Using biochemical reagents to remove components of mouse lung tissue that cause light scattering and light absorption, making it clear and achieve refractive index homogeneity and optical homogeneity.

Lung tissue morphology 3D imaging analysis

Performs cell-specific labeling of hyalinized mouse lung tissue, and uses microscopic observation and statistical analysis to characterize, localize, and quantify target proteins, nucleic acids, and subcellular structures.

In vivo lung tissue real-time imaging analysis services

CD BioSciences provides animal in vivo imaging technology services for real-time observation of activities occurring in lung tissue to help researchers directly monitor disease progression and conduct preclinical drug development at the in vivo level.

In vivo animal imaging

Utilize bioluminescence and fluorescent probe labeling with the aid of sensitive optical detection instruments to provide highly sensitive, clearly imaged, quantitatively accurate reports of preclinical disease research and drug discovery data.

Client needs to provide

• Experimental samples
• Experimental protocols (need to specify the animal model, the concentration and dose of the sample to be administered, the mode of administration, observation time points and other information).

CD BioSciences has a professional team and advanced imaging equipment. The whole process of lung imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us. We can also customize lung imaging analysis services for you according to specific needs.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!