As an important excitatory ionic glutamate receptor, NMDA receptor plays an important role in the development and formation of nervous system and synaptic plasticity. NMDA receptors usually consist of two essential subunits glun1 that bind glycine and two variable glun2 subunits that bind glutamate. Its dysfunction is closely related to mental diseases. Therefore, in-depth study of the conformation and function of NMDA receptors in physiological state and revealing the potential small molecule binding sites are very important for the development of new drugs targeting NMDA receptors.

Figure 1. Domain organization and architecture of NMDARs (Chou T H, et al. 2020).

NMDA Receptors Imaging Analysis

Currently, the researchers analyzed the structure of NMDA receptors in different small molecule binding states by cryo-electron microscopy. In addition, total internal reflection fluorescence microscopy (TIRFM) was used to observe the exocytosis of NMDA receptors. These methods fully explain the gating mechanism of NMDA receptor as ion channel, and enable researchers to deeply study the structure and pharmacology of NMDA receptor.

CD BioSciences has been committed to the development of fluorescent dyes and imaging technology for many years. We can provide you with imaging analysis services for the structure and function of NMDA receptors in physiological states, and we can also reveal potential small molecule binding sites for you, providing an important theoretical basis for drug design and new drug development.

NMDA Receptors Imaging Analysis Workflow

The following are the specific steps of NMDA receptors imaging analysis

Delivery

High quality image of NMDA receptor structure
Structural changes of NMDA receptors
Kinetic analysis of NMDA receptors
Other data that you need

Our Advantages

• Has high sensitivity, high resolution and high signal-to-noise ratio
• Study living substances and single molecule dynamics
• Experienced scientists provide experimental consultation
• Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of NMDA receptors imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.  

1. Chou T H, Tajima N, Romero-Hernandez A, et al. Structural basis of functional transitions in mammalian NMDA receptors[J]. Cell, 2020, 182(2): 357-371. e13.
2. Wang H, Lv S, Stroebel D, et al. Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors[J]. Neuron, 2021, 109(15): 2443-2456. e5.
3. Gu Y, Huganir R L. Identification of the SNARE complex mediating the exocytosis of NMDA receptors[J]. Proceedings of the National Academy of Sciences, 2016, 113(43): 12280-12285.

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Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!