Protein kinases play important regulatory roles in intracellular signal transduction, and their activity can be altered by mutation and binding away from the active site. Dysregulation of protein kinase activity is closely related to a variety of human diseases, such as cancer, cardiovascular and neurological diseases, which makes it an important target for drug discovery. Therefore, real-time and quantitative imaging analysis of protein kinases is very important.

Figure 1. The crystal structure of imatinib-bound form of the Abl kinase (Gagic Z, et al. 2020).

Protein Kinases Imaging Analysis

In the past few years, different molecular imaging techniques such as optical imaging, magnetic resonance imaging (MRI) and nuclear imaging have been used for disease biomarker detection and drug development. Meanwhile, molecular imaging can also be used for non-invasive real-time, dynamic imaging of protein kinase activity in living cells.

CD BioSciences has been committed to the development of imaging technology for many years. We have developed a protein kinase reporter gene that can measure and image the dynamics of kinase activity at the single-cell level to better develop protein kinase-related drugs.

Protein Kinases Imaging Analysis Workflow

The following are the specific steps of protein kinases imaging analysis

Delivery

Image of protein kinase
Activity of protein kinases under different conditions
Other data that you need

Our Advantages

• Analysis of kinase activity at the single-cell level
• Non-invasive real-time, dynamic imaging
• Experienced scientists provide experimental consultation
• Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of protein kinases imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.  

1. Kudo, Takamasa, et al. Live-cell measurements of kinase activity in single cells using translocation reporters[J]. Nature Protocols, 2018, 13(1), 155-169.
2. Gagic Z, Ruzic D, Djokovic N, et al. In silico methods for design of kinase inhibitors as anticancer drugs[J]. Frontiers in Chemistry, 2020, 7:873.
3. Zhang, L., Bhojani, M. S., et al. Molecular imaging of protein kinases[J]. Cell Cycle, 2008, 7(3), 314-317.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!