Misregulation of nucleic acid behavior can have adverse effects on cellular function and often leads to serious disease. Microimaging analysis can provide insight into the structure and function of nucleic acids in cells and tissues, and their interactions with other biomolecules.

Services Overview

CD BioSciences has a wide range of microimaging instruments with diverse capabilities for testing tissue sections, live cell samples, and more. Tissue nucleic acid imaging analysis enables researchers to directly observe and study the spatial distribution, subcellular localization and dynamics of nucleic acids in cells and tissues. Help researchers to reveal the association between nucleic acids and cellular functions and diseases, and help to find potential therapeutic targets and evaluate drug efficacy.

Tissue Nucleic Acid Imaging Services

CD BioSciences utilizes specific probes to help our clients achieve specific detection of RNA, DNA or other nucleic acid molecules in tissue sections/living cells and provide detailed information about the distribution and content of nucleic acids. Our services include but are not limited to:

Ratiometric fluorescence imaging services

Through control of probe selection and labeling methods, we track nucleic acids in real time in living cells and tissue sections. Help researchers observe the dynamic changes of nucleic acids in different cell types/tissue sections, different developmental stages or under different conditions, and provide clients with high spatial resolution image information.

➢ Provide detailed data reports, including information on cell profile, nuclear morphology and nucleoplasma ratio.
➢ Help clients obtain quantitative information such as the relative content, ratio and distribution characteristics of nucleic acids, and gain insight into the characteristics and distribution of nucleic acids at the cellular and tissue levels.

Single molecule fluorescence in situ hybridization (smFISH) services

CD BioSciences utilizes single-molecule fluorescence in situ hybridization (smFISH) technology to provide clients with optimized tissue nucleic acid imaging services, helping researchers visualize and quantify DNA or individual RNA molecules. Our services are widely used in genomics, cancer biology, neuroscience, and other fields, including:

➢ Visualization of target RNA molecules in fixed/living cells and tissues using oligonucleotide probes coupled to fluorescent sections.
➢ Help researchers to track the changes of individual RNA molecules over time and perform temporal analysis.
➢ Detect mRNA in cells and spatially localize and quantify it at locations such as the cytoplasm and nucleus.
➢ Provide insight into the spatial distribution and localization of RNA relative to other markers or proteins.

Single-molecule fluorescence in situ hybridization (smFISH) service workflow

CD BioSciences has a professional team and advanced imaging equipment. The whole process of tissue nucleic acid imaging services is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!