Understanding the protein composition in tissues can help us understand cell function, disease mechanisms, and drug responses. Imaging analysis technology can provide us with high-resolution images to visualize the expression and distribution of proteins and gain insight into their functions and interactions.

Services Overview

CD BioSciences utilizes advanced imaging technology to provide clients with tissue protein imaging analysis services, obtaining spatial distribution patterns of proteins in tissues, quantitatively analyzing protein expression levels and modification status, providing researchers with more comprehensive information about proteins. Our services are widely used in immuno-oncology, neuroscience and drug discovery.

Tissue Protein Imaging Services

Tissue protein mass spectrometry imaging services

CD BioSciences provides clients with mass spectrometry imaging analysis of proteins in tissues using MALDI technology. Our services enable rapid access to targeted protein profiles of frozen sections or FFPE tissue sections, providing researchers with efficient analytical solutions. Our services include:

MALDI mass spectrometry imaging analysis services

➢ Using MALDI technology, we can image advanced small molecules and transcriptome-related targeted proteins in the same tissue section.
➢ Map protein expression for clients, study metabolic activities, and delve into biological processes related to cellular interactions, tissue homeostasis, and disease progression.

Multiplexing analysis services

We can analyze more than 100 biomarkers simultaneously for our clients without the need for repetitive experiments.

➢ Each of our probes is uniquely labeled for mass, allowing for the visualization of multiple labeled proteins.
➢ Based on the mass spectrometry image data, we can quantitatively determine the molecular mass and expression of proteins for our clients, and detect and characterize protein modifications.

Multi-modality imaging analysis services

We can perform fluorescence microscopy, histopathology staining and MALDI mass spectrometry imaging on the same tissue section. Help researchers obtain more comprehensive biological information to better understand the distribution and interaction of proteins in tissues.

Spatial proteomics imaging analysis services

CD BioSciences provides spatial proteomic imaging analysis services for clients to qualitatively and quantitatively analyze up to 60 proteins on a single pathology section. Our service has the following contents:

Flexible experimental design solutions

According to clients' needs and sample characteristics, we provide flexible experimental design solutions, including the selection of fluorescent antibodies and combination matching, and free selection of sample regions of interest to meet clients' research needs.

Multiple fluorescent labeled antibody staining

Utilize multiple fluorescently labeled antibodies to stain tissue samples that help clients visualize the expression and localization of different proteins in tissues. Abundant protein expression information can be obtained, helping clients gain a deeper understanding of the functions and interactions of different proteins in the tissues.

High quality image acquisition

We use high-resolution microscopy and advanced imaging techniques to obtain high-quality images of tissue samples, which can provide information including:

➢ Detailed information on cellular and subcellular structures.
➢ Spatial distribution of proteins in the tissue.

Data analysis and processing

Through analysis and processing of the acquired image data, quantitative information about protein expression and spatial distribution can be extracted, including:

➢ Accurate spatial localization and expression analysis at the single-cell level of intact tissue images.
➢ Cell density and spatial distances, immune infiltration, intercellular interactions, spatial expression patterns between multiple functional proteins within cells, interrelationships, and correlation with disease.

Our Spatial proteomics imaging analysis services workflow

CD BioSciences has a professional team and advanced imaging equipment. The whole process of tissue protein imaging services is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!