Toxicology Fluorescent Imaging Panel
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Catalog NO: VIR030301
Size: 6 Vials
Introduction:Detect drug induced liver injury (DILI) early in the drug discovery process with Toxicology Fluorescent Imaging Panel. Drug-induced liver injury (DILI) is the leading reason for termination of drug discovery research projects and is a significant concern in attrition of new drug molecules reaching phase III clinical trials. DILI can manifest in hepatocellular, cholestatic, and steatotic forms differing in the type and pattern of tissue injury, biomarker expression and inflammation in the liver lobules.
Formulation:Vascular 680: Vascular probe (Leaks into sites of vascular damage or inflammation)
Transferrin Receptor 750: Transferrin receptor targeted probe (Iron metabolism marker in liver)
MMP 750 FAST x 2: Pan-MMP activatable probe (Secreted marker of stellate cells, Kupffer cells, macrophages, and neutrophils)
Annexin-V 750 Fluorescent Probe: Death/apoptosis probe (Marker on inflammatory cells; metabolic marker on tumor cells)
Renin 680 FAST: Renin activatable probe (Marker of tissue renin-angiotensin system activity)
Transferrin Receptor 750: Transferrin receptor targeted probe (Iron metabolism marker in liver)
MMP 750 FAST x 2: Pan-MMP activatable probe (Secreted marker of stellate cells, Kupffer cells, macrophages, and neutrophils)
Annexin-V 750 Fluorescent Probe: Death/apoptosis probe (Marker on inflammatory cells; metabolic marker on tumor cells)
Renin 680 FAST: Renin activatable probe (Marker of tissue renin-angiotensin system activity)
Category:Fluorescent Imaging Panels
Shipping Condition:Blue Ice
Therapeutic Area:Toxicology
Optical Imaging Classification:Fluorescence Imaging
Intended Use:For research use only. Not for use in diagnostic procedures.