Viruses are a variety of pathogens ranging from ten to several hundred nanometers in diameter. Most viruses are mainly composed of nucleic acids (RNA or DNA), structural proteins and lipid membranes. The protein coat of a virus can change and assemble to initiate viral infection and replication. Therefore, it is important to image and analyze the structure of viruses to obtain information about their size, morphology, composition and internal protein distribution.

Figure 1. Virus particles.

Viral Particle Structure Imaging Analysis

Fluorescence microscopy provides an easy imaging method for virus imaging. However, viruses are relatively small, with individual virus particles typically less than 220 nanometers in diameter. Due to the diffraction limit, optical microscopy cannot accurately visualize the structure of viruses. Fluorescence super-resolution microscopy bypasses the diffraction limit and becomes a novel tool for virus imaging.

CD BioSciences has been committed to the development of fluorescent dyes and imaging technology for many years. We can image thousands of individual virus particles through fluorescence super-resolution microscopy and rapid automated analysis platforms, and we can provide you with information on viral particle size, morphology, and its composition.

Viral Particle Structure Imaging Analysis Workflow

The following are the specific steps of viral particle structure imaging analysis

Delivery

High-resolution image of virus particles
Histogram of long axis length
Histogram of major/short axis ratio
Normal distribution curve of protein position
Other data that you need

Our Advantages

• Detector has high sensitivity at high speed
• Capable of overcoming the diffraction limit for high-resolution imaging
• Provides imaging analysis solutions for different viruses
• Experienced scientists provide experimental consultation
• Reasonable price and short turnaround time

CD BioSciences has a professional team and advanced imaging equipment. The entire process of viral particle structure imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.  

1. Castelletto S, Boretti A. Viral particle imaging by super-resolution fluorescence microscopy[J]. Chemical Physics Impact, 2021, 2: 100013.
2. McMahon A, Andrews R, Ghani S V, et al. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization[J]. BioRxiv, 2021.

*If your organization requires the signing of a confidentiality agreement, please contact us by email.

Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!