Cell Structure Imaging Analysis
Cell is the smallest unit of organism, which mainly includes cell membrane, cytoplasm, Golgi apparatus, ribosome, lysosome and so on. The structure of the cell is complex and exquisite and the various structures are coordinated with each other, so that life activities can be self-regulated and carried out in a highly orderly manner in a changing environment. Biomedicine and drug research usually rely on the quantitative analysis of cell structure, and live cell imaging is an effective method for cell structure analysis.
Figure 1. Cell structure.
Cell Structure Imaging Analysis
The standard imaging method of cell structure relies on fluorescence microscopy. Researchers mark the cell structure of interest with fluorescent dyes, and then observe the changes of cell internal structure in different life activities through the fluorescence microscope. However, fluorescent labeling is usually invasive and has disadvantages such as cytotoxicity, a large amount of internalization of fluorescent dyes, and rapid decrease in fluorescence intensity. The R&D team of CD BioSciences can provide you with customized fluorescent probes for imaging analysis of different cell structures according to your needs. Our fluorescent probes have the advantages of low cytotoxicity, no large amount of internalization, long-term imaging and observation, etc., which can help you visualize the cell structure and cell activity. In addition, we can also perform cell structure analysis through non-invasive methods such as bright field image analysis.
Figure 2. From cell cultures to quantitative biological information. (a) The standard workflow entails chemically staining the cell structures of interest, imaging them using fluorescence microscopy (in multiple light channels), and, finally, using these fluorescence images to retrieve quantitative biologically relevant measures about the cell structures of interest. (b) Uses bright-field images to generate virtual fluorescence-stained images (Helgadottir, et al., 2021).
Our Services
Our Advantages
- Provide customized fluorescent probes
- High-sensitivity optical system to capture high-quality pictures
- Fully automatic image analysis and data management
- Experienced scientists provide experimental consultation
- Reasonable price and short turnaround time
CD BioSciences has a professional team and advanced imaging equipment. The entire process of cell structure imaging analysis is operated by experienced technicians to ensure the accuracy of the experiment. If you have any needs, please feel free to contact us.
- Chessel, Anatole, and Rafael E. Carazo Salas. "From observing to predicting single-cell structure and function with high-throughput/high-content microscopy." Essays in biochemistry 63.2 (2019): 197-208.
- Helgadottir, Saga, et al. "Extracting quantitative biological information from bright-field cell images using deep learning." Biophysics Reviews 2.3 (2021): 031401.
*If your organization requires the signing of a confidentiality agreement, please contact us by email.
Please note: Our services can only be used for research purposes. Do not use in diagnostic or therapeutic procedures!